CORR-Variables

Streamlining clinical research with real-world data

🚀 What is CORR-Vars?

CORR-Variables is a Python package for extracting and analyzing data from the Charité Outcomes Research Repository (CORR).

It functions as a high-level connector on top of the Hadoop-based Health Data Lake (HDL), preprocessing raw clinical data into clinically meaningful, quality-checked variables to streamline research with real-world data.

🏥 Clinical Focus

Pre-defined clinical variables validated by medical experts

⚡ High Performance

Built on Polars for fast processing of large datasets

🔗 Easy Integration

Simple API that works with existing analysis workflows

Quick Start

🖥️ IMI Server (Recommended)

The CORR-Vars package is pre-installed and regularly updated on the IMI server:

# Connect to IMI server: s-c01-imi-app01.charite.de
# Activate the CORR-Vars environment
conda activate /data02/projects/icurepo/.pkg/env10

🔐 Access Required

If the conda environment doesn’t work, ask Patrick Heeren to be added to the miniconda-users group.

💻 Local Installation

For local development (requires GitHub access):

pip install git+https://github.com/cub-corr/corr-vars.git

⚠️ Access Required

This only works if you have access to the private GitHub repository.

Your First CORR Cohort

Get started in under 5 minutes:

# Import the main class
from corr_vars import Cohort

# Create your first cohort
cohort = Cohort(
    obs_level="icu_stay",
    sources={"cub_hdp": {"database": "db_hypercapnia_prepared", "conn_args": {"password_file": True}}}
)

# Add clinical variables
cohort.add_variable("age_on_admission")
cohort.add_variable("blood_sodium")

# View your data
print(f"Cohort: {len(cohort.obs)} patients")
print(cohort.obs.head())

🎯 Next Steps

• New to CORR-Vars? → Start with our Tutorials and Getting Started

• Need a specific variable? → Browse the Variable Explorer

• Want to contribute? → Read our Contributing New Variables guide

Documentation Structure

📚 Learning Resources

• Getting Started Tutorial - Your first analysis in 30 minutes

• Custom Variables Guide - Create your own clinical variables

• Contributing Guide - Add variables to the community catalog

• Troubleshooting - Solutions for common issues

Tutorials and Getting Started

🔧 API Documentation

• Cohort Class - Main interface for building cohorts

• Variable Types - Native, derived, and aggregation variables

• Data Sources - CUB-HDP, ReprodicU, and more

• Legacy Interface - Pandas compatibility layer

Cohort

📖 Complete Table of Contents

Learning Resources

• Tutorials and Getting Started
• Getting Started - Your First Analysis
  • Step 1: Environment Setup
  • Step 2: Basic Cohort Creation
  • Step 3: Exploring Your Cohort
  • Step 4: Adding Your First Variables
  • Step 5: Examining the Data
  • Step 6: Creating Aggregated Variables
  • Step 7: Setting Eligibility and Inclusion Criteria
  • Step 8: Applying Inclusion Criteria
  • Step 9: Generate Summary Statistics
  • Step 10: Save Your Work
• Tutorial 2: Advanced Variable Creation
  • Custom Aggregation Variables
• Tutorial 3: Multi-Source Analysis
• Tutorial 4: Working with Time-Series Data
• Tutorial 5: Complete Research Workflow Template
• Next Steps in Your CORR-Vars Journey
• Custom Variables Guide
  • Understanding Variable Architecture
  • Derived Variables with Custom Functions (py Parameter)
  • Native Variables (Database Extraction)
  • Source-Specific Variable Definitions
  • Best Practices for Custom Functions
  • Testing Custom Functions
  • Common Patterns and Examples
• Contributing New Variables
  • Overview
  • Development Workflow Overview
  • Step 1: Create a GitHub Issue
  • Step 2: Set Up Development Environment and Create Feature Branch
  • Step 3: Explore and Prototype in Jupyter Notebook
  • Step 4: Implement Clean Code in Configuration Files
  • Step 5: Verify Everything Works
  • Step 6: Create Pull Request
  • Step 7: Trigger Unit Tests with Interactive Auth
  • Step 8: Request Review and Merge
  • Post-Merge Follow-up
  • Common Pitfalls and Tips
  • Additional Resources
• Troubleshooting Guide
  • Database Connection Issues
  • Variable Loading Issues
  • Memory Issues
  • Data Quality Issues
  • Time-Related Issues
  • Custom Variable Issues
  • Performance Issues
  • File and Save/Load Issues
  • Getting Help

API Reference

• Cohort
  • Cohort Workflow
  • Class Reference
• Core Module
  • Variable Architecture
  • Examples
  • Class Reference
• Aggregated Variables
  • Overview
  • Variable Types
  • Time Constraints and Filtering
  • Advanced Examples
  • Best Practices
  • Class Reference
• Data Sources
  • Available Sources
  • Overview
  • Multi-Source Configuration
  • Source-Specific Variables
  • Variable Loader
  • Base Sources Module
• Utils
  • Time Primitives
  • DataFrame Utilities
  • Extraction Helpers
  • TableOne Export
  • Logging
  • Debug
  • Overview

Core Architecture

🏥 Observation Levels

Choose your analysis unit:

• Patient - One row per unique patient (patient_id)

• Hospital Stay - Complete hospitalization periods (case_id)

• ICU Stay - Individual intensive care episodes (icu_stay_id)

• Procedure - Specific surgical/medical procedures (procedure_id)

📊 Variable Types

Rich clinical data hierarchy:

• Native - Direct database extractions

• Derived - Computed from existing variables

• Static - Single values per observation

• Dynamic - Time-series measurements

🔍 Explore Available Variables

Browse our 300+ pre-defined clinical variables in the interactive Variable Explorer

Real-World Example

Here’s how researchers use CORR-Vars for clinical studies:

# Build an ICU sepsis cohort
cohort = Cohort(obs_level="icu_stay", sources={"cub_hdp": {"database": "db_hypercapnia_prepared"}})


# Add a static variable
cohort.add_variable("sofa_score_imputed")

# Add time-series biomarkers
cohort.add_variable("blood_lactate")
cohort.add_variable("blood_creatinine")

# Apply inclusion criteria
cohort.include_list([
    {"variable": "age_on_admission", "operation": ">= 18", "label": "Adults"},
    {"variable": "sofa_score_imputed", "operation": ">= 2", "label": "Organ dysfunction"}
])

# Generate publication-ready summary
table1 = cohort.tableone(groupby="inhospital_death")
print(f"Study cohort: {len(cohort.obs)} patients")

📈 Publication Ready

CORR-Vars concepts are quality-checked by attending physicians at Charité Berlin before being used for:

• Critical care outcomes research

• Machine learning model development

• Health services research

• Quality improvement studies

Community & Support

🐛 Found a Bug?

Report issues or request features on GitHub

https://github.com/cub-corr/corr-vars/issues

💬 Need Help?

Check our Troubleshooting Guide guide or contact the team

🤝 Want to Contribute?

Add new variables to help the research community

Contributing New Variables

—

🏥 Developed at Charité Berlin

Advancing clinical research through innovative data science tools

Development Team:

• Moritz Thiele

• Pedram Ramezani

• Noel Kronenberg

• Julian Felber

• Sophie Hollerbach

• Dario von Wedel

…and the entire CORR team 🙏

📊 Project Stats

• 🏥 Version: 0.5.0

• 📅 Active Development: Since September 2024

• 📈 Publications: 10+ active projects pending publication

• 👥 Users: Research teams across Charité departments with a focus on critical care outcomes research

• 🔗 GitHub: CORR-Vars Repository